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Studies have shown that IGF-l and IGF1R mRNA expression in cultured young intervertebral disc cells is higher than that in mature cells, and the decrease of IGF-l dependent protein polysaccharide synthesis in rat NPCs is due to the downregulation of IGF-IR in late senescence (Osada et al., 1996

Consistently with a previous report [21], rat amylin S34P mutation appeared to fit the peptide binding pocket of CTR more suitably with CTR E123 and N124 (Figure 7C)

In the STAIR XI meeting this point was made more explicit and recommended to be taken into account in the design of preclinical studies [25, 26]

Antioxidant, free-radical, and peroxide defenses

Here, it was shown that ALA intake enhanced the quality of life of patients with diabetic neuropathy, reduced major symptoms and triglycerides levels

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