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96 Moreover, the function of tyrosine-derived fumarate in modulating TLS and chemosensitivity in EOC has been uncovered

The activity of catalase (CAT) and superoxide dismutase (SOD)-like enzymes is responsible for the effectiveness of these antioxidants, enabling them to neutralize destructive ROS (including H 2 O 2 , superoxide anions), giving them antioxidant effects ( Figure 5B )

This loop is the storage mechanism for B12 in normal mammals as the intrinsic factor from the stomach holds onto the B12 and saves it for the ilium to recover and send to the liver

Moreover, TNF- contributes to endothelial dysfunction by activating the NF-B and mitogen-activated protein kinase (MAPK) signaling pathways, which in turn promote the transcription of additional pro-inflammatory cytokines and apoptosis-related genes

Funding This research and the APC were funded by the National Institute of Health grant number 1K99HL140049-01 (AMM)

Likewise, Kasetsirikul et al