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Simultaneously, the activation of the PI3K/Akt pathway leads to the phosphorylation and activation of endothelial Nitric Oxide Synthase (eNOS)
As crucial regulators of local immune responses and tissue repair, macrophages in diabetic wounds show dysregulated switching from M1 to M2, resulting in a poor regenerative environment, exacerbated tissue damage, and delayed wound healing 63
Depending on age, diet, and health status, supplementation may be necessary to meet recommended levels
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PMC 4753969
