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The expression of SIRT5 is increased in the proximal tubular epithelial cells (PTECs) of mice under IRI and in the human proximal tubular epithelial cells (hPTECs) exposed to oxygen/nutrient deprivation (OND)
Jowsey, Glutathione transferases
doi:10.1016/j.diabres.2008.12.018 [DOI] [PubMed] [Google Scholar] 62.Hearn L, Derry S, Moore RA
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The American Journal of Clinical Nutrition
Due to upstream DNA hypomethylation and high levels of H3K27ac and H3K4me3, the expression level of GPX4 in OC tissues is higher than that in normal tissues, and it is negatively correlated with the prognosis of patients, indicating that aberrant GPX4 expression in cancer may result from epigenetic regulation (121)
