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Based on these data, together with the earlier studies on the specificity of monomeric macrocycle binding to Met, we conclude that the observed downstream phosphorylation events are triggered by the specific activation of Met by the dimeric macrocycles

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Cent Nerv Syst Agents Med Chem 9:300306 [DOI] [PubMed] [Google Scholar] Kawas LH, McCoy AT, Yamamoto BJ, Wright JW, Harding JW