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Not only that, the IDoi@TBC-Hf nanoparticles formed by loading the IDO inhibitor (IDoi) indoleamine 2,3-dioxygenase into TBC-Hf (a new nMOF) using the highly porous structure of the nanometal-organic framework (nMOF) can reverse the inhibitory tumor microenvironment by releasing IDoi after local injection, and combined with PDT can induce ICD and further stimulate the immune system, leading to infiltration of CD4 + T and CD8 + T cells in the TME and effectively controlling both local and distant tumors (188)

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Sleep 33(7):889900 Cardinali DP, Pagano ES, Scacchi Bernasconi PA, Reynoso R, Scacchi P (2013) Melatonin and mitochondrial dysfunction in the central nervous system

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Lactate and energy metabolism in male germ cells

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Both approaches have theoretical merit, though head-to-head comparisons do not exist in the published literature

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Raad et al., 2009

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B., Das, A

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