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Mitochondrial Dysfunction and Diabetes Well established data demonstrate that mitochondrial dysfunction, particularly as it relates to the processes of oxidative phosphorylation, is contributory to the development of encephalomyopathy, mitochondrial myopathy, and several age-related disorders that include neurodegenerative diseases, the metabolic syndrome, and diabetes

doi: 10.3389/fphar.2025.1490480 Received 03 September 2024 Accepted 01 April 2025 Published 16 April 2025 Volume 16 - 2025 Edited by Jae-hyeon Park, National Institute on Aging (NIH), United States Reviewed by Rajbir Singh, Patanjali Research Institute, India Naveen Sharma, Chung-Ang University, Republic of Korea Updates Copyright 2025 Wang, Wei, Chen and Chen

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During the 6-month open-label extension, both groups improved or maintained cognitive performance
Schmidt T.G.M., Batz L., Bonet L., Carl U., Holzapfel G., Kiem K., Matulewicz K., Niermeier D., Schuchardt I
