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1 Introduction Male infertility is a significant global health concern, affecting approximately 8-12% of couples of childbearing age ( Male infertility specifically refers to any condition in which a males reproductive system impairs the ability to achieve a successful pregnancy

Activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) promoted 4-HNE detoxification, restored APN signaling and vascular regeneration, and ultimately improved diastolic function in diabetic hearts (Roy et al., 2022)

doi: 10.1530/rep.1.0511 128 ReaderKLHeathDALunSMcIntoshCJWesternAHLittlejohnRPet al

doi: 10.1152/japplphysiol.00431.2011

However, there are still several outstanding issues in this area that have not been adequately addressed

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