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However, intense loss of Purkinje cells is evident, and there is great diversity in the morphology of the storage cytosomes, with many membranous cytoplasmic bodies in caudal brainstem nuclei

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PI3K/Akt and MAPK pathways have been shown to mediate downstream signaling of IGF-1 in these cells, although the relative importance of these pathways seems to differ depending on the model systems analyzed