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Age: The risk increases between ages 30-50 as discs become less flexible

A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

In contrast, intramuscular injections allow for nearly 100% absorption, making them a more reliable option for many people

Learn more about the causes of vitamin B12 deficiency

Is a higher dose always better