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It depends on two primary variables: Volume of distribution (Vd) Clearance (CL) Formula: t = (0.693 Vd) / CL Vd = how widely the drug is distributed CL = how quickly it's eliminated Interpreting the Curve KOTC Tip: It takes ~45 half-lives to reach steady state or complete elimination

When people stopped the treatments, their skin gradually returned to its original color