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NNMT is highly expressed in fat tissue, which has made its inhibition a focus of metabolic research

Studies show the consuming an excessive amount of vitamin B12 may: Increase the risk of cardiovascular events in people with diabetic nephropathy : A study published in JAMA sought to determine whether B vitamin therapy was able to slow the progression of diabetic nephropathy (kidney damage due to diabetes) and prevent vascular complications

For people with serious deficiencies or absorption issues, this difference can be life-changing

What is the best type of B12 for a shot

Research comparing fasted vs fed administration of NNMT inhibitors consistently shows 3040% lower fat oxidation rates in fed-state protocols, even with identical doses