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An ideal hepatic in vitro model should exhibit sufficient CYP activities, necessary for metabolic activation of NAs

We performed further refinement from literature and by using the human metabolic networks in the HumanCyc database (Trupp et al, 2010) and Recon3D (Brunk et al, 2018)

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Then we further detected HIF-1 expression and localization in 30 UC tissues and 20 healthy colon tissues with IHC assay
[DOI] [PubMed] [Google Scholar] Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH (2008) Self-treatment of opioid withdrawal using kratom (Mitragyna speciosa korth)

It occurs when excess sebum binds pollutants, dirt, and dead cells to the skins surface, leading to clogged pores
