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Int J Mol Sci 22:8894

Conclusion In conclusion, this systematic review demonstrates that the APOE4 genotype in mice is associated with compromised blood-brain barrier integrity, reflected by consistent pathogenic alterations in vascular morphology, cerebral blood flow dynamics, and mechanistic pathways linking ECM remodelling, junctional instability and metabolic dysregulation

Summers S

& Gssl, M

doi: 10.1002/mrd.21122
Lactate (lactic acid) builds up due to metabolic stress and fatigue given to a muscle
