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For this reason, there is growing interest in targeting the NRF2 signaling axis as a therapeutic strategy in HCC, with the aim of altering its antioxidant defenses and promoting ferroptotic cell death by improving lipid peroxidation

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Targeting of superoxide dismutase and catalase to vascular endothelium

95%CI 1.0581.250

In gynecologic malignancies, fisetin induces apoptosis and necroptosis, downregulates survival and proliferative pathways, inhibits migration and invasion, and enhances sensitivity to platinum agents and targeted therapies, particularly in ovarian and cervical cancer models

The effective and close bidirectional interactions of the oocyte with its neighboring cells, granulosa, during folliculogenesis are required for the later development of the embryo and pregnancy outcome