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Description
Eph receptors to which the ADCs of the invention specifically binds to include but are not limited to EphA1, EphA2, EphA3a, EphA3b, EphA4, EphA5a, EphA5b, EphA6, EphA7, EphA8, EphB1, EphB2a, EphB2b, EphB3, EphB4 and EphB6
The peptide's oral bioavailability is low (58%), but it accumulates preferentially in inflamed colonic tissue, making systemic absorption less critical
Similar results have been reported by Reddy et al
No published data establishes an optimal rest period
Clementi A, Virz GM, Milan Manani S, Battaglia GG, Ronco C, Zanella M
This vent allows air to escape as you inject fluid in
