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Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Thyrotoxicosis induced by administration of LT4 to healthy volunteers and those with thyroid nodules also induces a procoagulant state, associated with increased levels of FVIII, FIX, FX, VWF, fibrinogen D-dimer, and PAI-1 with delayed fibrin clot lysis and a shortening of the APTT, but with an inconsistent impact on clot structure parameters potentially based on subtle mechanistic differences between endogenous and iatrogenic hyperthyroidism [118,119,120,121]

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Although the SUMOylation of IGF-IR at three evolutionarily conserved lysine residues (K1025/1100/1120) in IGF-IR is dispensible for its kinase activity, SUMOylation is essential for its nuclear translocation [81]

The post-menopausal women using hormone replacement therapy (HRT) have been reported to have 5% greater muscle strength than those not using HRT ( vastus lateralis muscle samples of nine healthy monozygotic female twin pairs (5462-years old) discordant for HRT showed that miR-182 and miR-223 were significantly downregulated in HRT treated groups as compared to non-treated groups (Olivieri et al., 2014)