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Pathological astrocytes in the context of PD have deficient mitochondrial function 208 and decreased transmitophagy, the latter being instrumental for supporting energy production in dopaminergic neurons 210
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Indeed, the homocysteine levels in patients with the risk variant (TT) were higher and their high-density lipoprotein (HDL) cholesterol levels were lower than persons not carrying this MFTR variant [9]
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