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[DOI] [PMC free article] [PubMed] [Google Scholar] [127].Paz-y-Mino C, Carrera C, Lopez-Cortes A, Munoz MJ, Cumbal N, Castro B, Cabrera A, Sanchez ME, Genetic polymorphisms in apolipoprotein E and glutathione peroxidase 1 genes in the Ecuadorian population affected with Alzheimers disease

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Thus, excessive production of ROS mediates hyper-inflammation and generation of cytokine storm that directly determine both ARDS development and ARDS course severity

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Some pathogenic bacteria produce toxins (for instance cholera toxin) that permanently activate the adenylate cyclase of the enterocyte