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John Wiley & Sons, Inc

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Summary Investigations thus far into the metabolism of amino acids in cancer has begun to highlight a nuanced network, where in many cases, tracing of the uptake and use of a specific amino acid may not reveal the real functional output of the pathway

In treating solid tumors, developing more tumor-targeting ASNase is one aspect, and the SLC1A3 inhibitor mentioned earlier also provides an idea to solve this problem

Recent investigations reported that cerebral blood flow is usually increased by insulin, but that this action is blunted by insulin resistance, producing harmful effects such as mitochondrial dysfunction, oxidative stress, and decreased neuronal viability and eventually CD (van Sloten et al., 2020)
