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The amyloid paradox: Amyloid--metal complexes be neurotoxic and neuroprotective

doi: 10.1016/j.yjmcc.2015.12.003

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Exhibit I also folds those studies into a broader literature review that includes retrospective human work in knee pain, interstitial cystitis, and intravenous infusion tolerability

Additionally, dimensionality reduction techniques, including Singular Value Decomposition (SVD) and Principal Component Analysis (PCA), can lower data volume and computational complexity, thus improving overall efficiency

This is not a gap awaiting the next paper it has been explicitly acknowledged in the primary review literature for over four decades