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GBM is the most aggressive, infiltrative and prevalent type of gliomas and is responsible for 30% of primary brain tumors and the highest death incidence among other primary brain tumors [383]

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Recent studies emphasized that regulatory frameworks for probiotics and other biotics are advancing rapidly, especially for LBPs, for which conventional drug regulations often do not align well with live microbial products that possess complex, multifactorial mechanisms of action (524)