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Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane, a chemical source of triplet-excited ketones

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Abbreviations BBB: Blood brain barrier BSP: Bisulfite sequencing PCR CNS: Central nervous system COVID-19: Coronavirus disease 2019 CpG: Cytosine-phosphate-guanine DML: Differentially methylated locus HCY: Homocysteine MS: Multiple sclerosis PET-CT: Positron emission tomography - computed tomography ROCF: Rey-Osterrieth complex figure ROS: Reactive oxygen species RT-qPCR: Real time quantitative polymerase chain reaction SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TFBS: Transcription factor binding site VCD: Visuoconstructive deficiency WHO: World Health Organization References Centers for Disease Control and Prevention (CDC)

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Nat Commun 16 , 6990 (2025)

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Respiratory Precaution: Individuals with a history of asthma should consult a healthcare professional before use, as inhaled forms of glutathione may trigger respiratory sensitivities

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Furthermore, a key duty for medical practitioners is to understand, foresee, and minimize potential health risks during space flight (199)

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However, due to factors such as tumor location and size, presence of other comorbidities, and inoperability, surgical treatment is only applicable in 1020% of cases, with a 5-year survival rate as low as 30% [8, 9]

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