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Description
Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane, a chemical source of triplet-excited ketones

Abbreviations BBB: Blood brain barrier BSP: Bisulfite sequencing PCR CNS: Central nervous system COVID-19: Coronavirus disease 2019 CpG: Cytosine-phosphate-guanine DML: Differentially methylated locus HCY: Homocysteine MS: Multiple sclerosis PET-CT: Positron emission tomography - computed tomography ROCF: Rey-Osterrieth complex figure ROS: Reactive oxygen species RT-qPCR: Real time quantitative polymerase chain reaction SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TFBS: Transcription factor binding site VCD: Visuoconstructive deficiency WHO: World Health Organization References Centers for Disease Control and Prevention (CDC)

Nat Commun 16 , 6990 (2025)

Respiratory Precaution: Individuals with a history of asthma should consult a healthcare professional before use, as inhaled forms of glutathione may trigger respiratory sensitivities

Furthermore, a key duty for medical practitioners is to understand, foresee, and minimize potential health risks during space flight (199)

However, due to factors such as tumor location and size, presence of other comorbidities, and inoperability, surgical treatment is only applicable in 1020% of cases, with a 5-year survival rate as low as 30% [8, 9]
