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This review aims to systematically elucidate the central hub role of the gut microbiota-enterohepatic axis in dietary nutrient metabolism, with emphasis on exploring the association mechanisms between gut microbiota-mediated amino acid metabolism and DKD, and reviewing research progress on natural bioactive compounds targeting the gut microbiota-enterohepatic axis for DKD intervention

Additionally, the use of multi-strain formulations or next-generation probiotics, such as Akkermansia muciniphila and Faecalibacterium prausnitzii , may offer superior anti-inflammatory effects and mucosal repair capacities, thus making them promising candidates for future clinical and preventive applications

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