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The primary GBM is caused by three key molecular signaling pathways: p53, Rb, and PI3K [277]

doi: 10.3389/fphar.2021.757508 202 ZhangL.ZhaoM

55 Apart from the calcium-dependent eNOS activation, exercise also stimulates hormone and growth factor secretions such as norepinephrine (NE) and vascular endothelial growth factor (VEGF), which may bind to 3-AR and VEGFR in endothelial cells and further activate PI3K/AKT signaling and subsequent eNOS phosphorylation

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demonstrated that high glucose induces ferroptosis in astrocytes by altering iron metabolism and suppressing the SLC7A11/GPX4 pathway in db/db mice [160]

This knowledge will be crucial for optimizing their therapeutic efficiency and managing their cytotoxic effects, thereby harnessing their potential to improve cancer treatment outcomes