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227 In an in silico screen to identify inhibitors of the Rac1p67 phox interaction, a fundamental step in NOX2 activation, compound 16 (Phox-I1) was identified as a new NOX2 inhibitor

doi: 10.1136/gutjnl-2017-314057 11 SantoroAAngelicoGTravaglinoAInzaniFArciuoloDValenteMet al

Understanding the mechanism of action of methotrexate could be instructive in the appropriate use of the drug and in the design of new regimens for the treatment of RA

They highlight promising candidates for further testing, bridging computational predictions and therapeutic development

** Origin Country: Japan ** The result depends on individual metabolism

h , Fold change (log 2 ) in indicated whole cell or ER metabolites from ER-tag HEK293T cells treated with glucose deprivation compared to glucose repletion