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Footnotes Mirza Hasanuzzaman and Kamrun Nahar have contributed equally to this work

Looking forward to see what happens with my skin over a 6 month period

The regulatory elements within the ARE sequences of these genes confer specificity to the NRF2 transcriptional signature, which varies according to cell type, intensity, and duration of the stimuli (Lee et al

Therefore, in pharmacological management, it is essential not only to employ combination therapies to enhance dopaminergic signaling across multiple pathways and manage motor complications, but also to actively develop novel agents with multi-target profiles and explore treatments targeting non-dopaminergic systems that possess disease-modifying potential

Due to the fact that changes in calcitriol levels alter plasma calcium and PTH levels it is not clear what the exact mode of action is for calcitriol relative to renal phosphate retention

Supplementation with pyridoxine, vitamin B12 and folic acid may be considered