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The opposite gating residues on the intracellular side are Y211 and Y447 which pack together to form a part of the intracellular gate
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doi: 10.3233/JAD-171110
Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN: Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid
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L-carnitine reduces acute lung injury via mitochondria modulation and inflammation control in pulmonary macrophages
