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Stacking peptides makes sense when two conditions are met: the compounds work through different mechanisms, and their side effect profiles do not compound each other in dangerous ways

Prompt identification and management are essential to prevent complications such as megaloblastic anaemia, peripheral neuropathies, cognitive impairment and other neuropsychiatric manifestations

Comment: A commenter suggested that CMS consider including language that promotes avoidance of the IDR process when findings surpass a certain level of seriousness

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