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In addition, sFlt-1 enhances endothelial dysfunction previously established by OS

Revisiting oxidative damage in ALS: microglia, nox, and mutant SOD1

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CYP1A2 is responsible for the process of demethylating caffeine, resulting in the production of the main metabolites [62] paraxanthine (1,7-dimethylxanthine, around 84%), theobromine (3,7-dimethylxanthine, 12%), and theophylline (1,3-dimethylxanthine, 4%)

doi: 10.3390/molecules18033292