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Concluded from the study that greater blood levels of vitamin B12 (550 pg/mL) and lower levels of folate (6.2 ng/mL) may be directly related to the increased risk of all-cause death, either separately or together [77, 84-86]

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As deduced from an X-ray crystallographic analysis of 43 in complex with ERAP2 it was concluded that the three first specificity pockets of the enzyme was of particular importance for binding to the enzyme (Zervoudi et al., 2013)

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