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doi: 10.3389/fimmu.2020.01229 238 SamiecP.Drews-BotschC.FlaggE.KurtzJ.SternbergJ.ReedR.et al

Multiple studies have reported that Epithalon administration can extend both mean and maximum lifespan by 10-25% or more compared to control animals - effects approaching those seen with caloric restriction

Some drug trials based on the A cascade have documented adverse side effects like brain hemorrhages
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