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Administration of high-fat diet promotes the production of ROS, along with the elevation of tumor necrosis factor-alpha (TNF-) and adipokine secretion, thereby resulting in chronic inflammation [41]

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Study on the relationship between insulin growth factor 1 and liver fibrosis in patients with chronic hepatitis C with type 2 diabetes mellitus

Lindert, J., et al

While mechanistic understanding has advanced, countless studies over the last few decades also brought up many controversies including the identification of specific targets for protein binding and its relevance to toxicity, the role and sources of oxidant stress and lipid peroxidation (LPO), and the importance of inflammation as a mechanism of injury and recovery