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doi: 10.1016/j.pharep.2014.09.004

In addition, the pathophysiological significance of HIF-1 in bone formation, bone absorption, angiogenesis, erythropoiesis, oxidative stress, energy metabolism, iron death, etc

Curr Opin Investigational Drugs

The arrival of a child in the family is a dream for many couples

Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation
