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To counter GST-mediated resistance, various GST inhibitors and prodrugs specifically targeting cancer cells with elevated GST expression have been developed, showing considerable therapeutic promise
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The authors of this Review describe the current first-line treatment options for EGFR-mutant NSCLC, discuss mechanisms of acquired resistance to third-generation EGFR TKIs and new promising treatment strategies, such as bispecific antibodies, next-generation TKIs, antibodydrug conjugates, immunotherapy approaches and targeted protein degraders.
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