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Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro

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Bronspiegel-Weintrob, N

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, Yan, F

S -glutathionylation of eNOS is thought to be a pivotal switch providing redox regulation of cellular signaling, endothelial function, and vascular tone.86 Furthermore, while uncoupling of eNOS leads to potent inactivation of NO through its reaction with superoxide (O 2 ), this reaction forms the potent oxidant peroxynitrite (ONOO ) (Figure 1)