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Caspase-1 also cleaves GSDMD, which subsequently translocates to cell membranes to form pores, thereby mediating the release of pro-inflammatory cytokines and inducing cellular pyroptosis

It is key for a responsive metabolism

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doi: 10.1002/mds.22564

Key protocol elements include proper dosage calculation (typically 5-10mg per cycle), consistent daily administration timing, appropriate cycle length (10-20 days), and adequate rest periods between cycles