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For people in higher-risk categories, safety depends entirely on thorough screening and clinical oversight

Small clinical trials using 500 mg of oral glutathione daily have shown modest reductions in melanin index, mainly in sun-exposed skin, though results are inconsistent across studies

Some common immediate side effects may include swelling, bruising, pain, burning, itchy skin, and discomfort

The first in vitro study reporting these changes was conducted using SFN on prostate and colon cancer cell lines, where the inhibition of HDAC activity was accompanied by global increases in histone H3 and H4 acetylation on the promoter regions of p21 and bax genes, facilitating cell-cycle arrest and apoptosis in the context of cancer chemoprevention ( Reference Myzak, Karplus and Chung 53 )