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Heise T, DeVries JH, Urva S, Li J, Pratt EJ, Thomas MK, et al

condition which allow alkylation of the sulfhydryl group of GSH with the maleimide typically require that the maleimide (such as NEM) is (initially) present at a concentration of at least 0.0001 mM, preferably at least 0.001 mM, more preferably at least 0.01 mM, even more preferably at least 0.1 mM, yet even more preferably at least 1 mM or even at least 2 mM

NMR-based observations of oxidation kinetics on the time scale of seconds To explore the potential of LLC for the detection of fast oxidation processes, we monitored the transformation of glutathione, GSH, into its oxidized form, glutathione disulfide, GSSG (Fig

2016 [cited 2025 Feb 1]

Of note, treatment of KRAS-mutant LUAD with HG106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival

Moreover, the presence of RO can enhance the generation of RO, further exacerbating cellular damage