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Long-term human RCTs for systemic injectable use are limited

These may include: High-Performance Liquid Chromatography (HPLC) Mass Spectrometry (MS) Nuclear Magnetic Resonance (NMR) spectroscopy These methods can detect changes in the chemical composition of the product, including the formation of degradation products or impurities

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In clinical studies in patients with interferon alfa-refractory hairy cell leukemia, a complete response to pentostatin therapy generally was defined as clearing of peripheral blood and bone marrow of hairy cells