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In contrast, the Thr1273Ala substitution likely modifies the S tail conformational accessibility for coatomer binding, which results in its enhanced retention in early secretory compartments 11

Epigenetics 13 (1), 63

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Finally, melatonin is produced through the methylation of N-acetylserotonin by N-acetylserotonin O-methyltransferase (ASMT, previously identified as hydroxyindole-O-methyltransferase or HIOMT) [2,10,11,12,13]
Cell 187, 235256

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