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Polyalanine (PA), poly(alanine-co-phenylalanine), and poly(alanine-co-leucine) conjugated to PEG or poloxamer are some examples of thermosensitive copolymers

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J Pediatr Surg

Mostly because its having a moment. BPC-157 has been a frequent guest on the Joe Rogan podcast, receives backing from Gary Brecka (a purveyor of nasal-sprayed BPC-157 for $375 a pop), and got a boost on Andrew Hubermans popular neuroscience-ish podcast

The Phase 2 combination trial in type 2 diabetes reported that, by its 32-week endpoint, the cagrilintide-plus-semaglutide arm reached 15.6% mean weight loss versus 8.1% for cagrilintide alone and 5.1% for semaglutide alone with the combination curve already diverging upward through the early months (Frias et al., 2023)