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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

Activation of the coagulation system: This can lead to hypercoagulation and vascular blockage

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44% on Pd) [71]

Statistical Analysis Statistically analyzed data were presented as the mean standard error of the mean (SEM)
