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Much of Noopept cognitive effect may be mediated through its metabolite cycloprolylglycine (cPG), which concentrates preferentially in the hippocampus and has been shown to reduce hippocampal cell death, increase BDNF mRNA, and modulate inflammatory cytokine expression

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In addition, Hcar2 is expressed on epithelial cells of the retina, colon, and apical intestine, as well as keratinocytes of the skin [55, 65]

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