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this nanoparticle drug delivery system has been shown to enhance chemotherapy sensitivity in ovarian cancer (113)

In addition, increased foreign viral antigens from EBV reservoirs, SARS-CoV-2 or vaccine viral vectors, in individuals carrying ancestral HLA class II alleles with the ability to detect a greater number of antigens and activate a greater number of T and B cells, could increase the activation of autoreactive T cells due to their promiscuity and molecular mimicry of self-antigens with viral antigens (112)

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1

Regardless of the explanation, these data suggest that other more frequent administration schedules of pemetrexed, such as bi-weekly regimens, should be explored to optimise its antiproliferative effects

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