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PLoS ONE 15 , e0228212 (2020)

Conversely, progranulin and its derivative peptide atsttrin can bind to the TNF receptors to inhibit the phenotype and function associated with LPS-induced M1 macrophage polarization via the nuclear factor kappa-B (NF-B) and MAPK signaling pathways [49]

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Omicron and its subvariants have drifted so much from the original Covid strain that the virus is able to slip past the protective antibodies induced by the vaccines
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