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doi: 10.1345/aph.1A035
This reduction consists of two steps
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An increase in the Akkermansia spp population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice (in Eng)

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Toxicology 458:152840 Feagan BG, Rochon J, Fedorak RN, Irvine EJ, Wild G, Sutherland L, Steinhart AH, Greenberg GR, Gillies R, Hopkins M (1995) Methotrexate for the treatment of Crohns disease