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10.33549/physiolres.934015 174 LobertS.VulevicB.CorreiaJ

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Woolbright B.L., Jaeschke H

Assuming that there is enough extracellular H 2 O 2 present at sites of infection, NET-bound MPO could generate reactive hypohalous acids in the immediate vicinity to trapped pathogens and thus effect their killing

While the phase 2 CENTAUR trial showed a slowing of functional decline, the subsequent phase 3 PHOENIX trial failed to meet its primary or secondary efficacy endpoints, leading to the drugs voluntary withdrawal from the market (7)

These values reflect reported experimental parameters only and are provided strictly for research use, never for human application

Furthermore, CRISPR enables scarless editing and reduces genomic instability, facilitating the development of GMP-compliant MSC lines