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While genetic and environmental determinants are well recognized, diet constitutes a modifiable factor capable of shaping immune regulation, inflammatory pathways, and gut microbiota compositioncentral mechanisms in autoimmune disease pathogenesis

Ducey, J (2018)

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ERGO directly inhibits histamine-metabolizing enzyme and promotes polarization of anti-inflammatory microglia We hypothesized that ERGO may change microglial phenotype by inhibiting HNMT because ERGO potentially inhibits the enzymatic activity of histamine N-methyltransferase (HNMT) although detailed inhibition analysis has not yet been examined [42]

APP, amyloid precursor protein

G., Morrall, C