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doi: 10.1042/bst0280056

Hippocampal neurons cultivated in high Hcy or low folate media consistently showed decreased cell survival (Kruman et al., 2005

Interestingly, UPR is also activated in neurodegenerative tauopathies such as AD

2.4 Determination of the murine estrous cycle Vaginal smear cytology, which includes washing with physiological saline, was used to obtain vaginal lavage fluid from the selected mice every day for eight consecutive days, starting on the 15th day of the experiment

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Only six new fragments showed a peak reduction of greater than 20% in the CPMG assay (Supplementary Table 2), a similar degree of hit validation to the first XChem screen